Our research

Fight for Sight funds pioneering research to prevent sight loss and treat eye disease in adults and children. Each year, we provide a range of funding opportunities for research teams based in the UK who are attached to recognised academic or medical institutions. You can read summaries of our research projects below.


By research category


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Cell-cell junctions in retinal disease: The role of ARHGEF18/p114RhoGEF

Researchers aim to identify the molecular mechanisms by which defective p114RhoGEF leads to malfunctioning of cell-cell junctions in retinal pigment epithelial cells and photoreceptors, and how such defects lead to degeneration of these cell types.

October 18 - September 21
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Investigating the unexpected role of transport motors inside light-detector cells

A new line of research that could lead to developing treatment for inherited retinal disorders

October 16 - September 19
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Investigation and treatment of intronic ABCA4 mutations in patients with inherited retinal dystrophy

A proportion of the causative mutations include those that occur within introns of the gene.

October 17 - September 20
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Novel genomic approaches in the elucidation of inherited retinal disease

October 17 - October 20
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Molecular mechanism of opsin transport and its relevance to photoreceptor degeneration

The aim is to identify proteins that bind opsin and move it into the photoreceptor outer segment.

September 18 - August 21
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Searching for more of the genes behind inherited central vision loss

Taking the first step towards targeted treatment and helping families plan for the future

January 15 - February 16
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Overcoming the barriers to gene therapy in Leber congenital amaurosis

Finding out which patients might benefit in a step towards clinical trials.

April 15 - August 15
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Understanding inherited blindness due to light-sensor cells with ‘broken antennas’

Identifying targets for treatment and potential new drugs to prevent damage to the retina in Bardet Biedl syndrome

February 15 - January 16
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Choosing the right cells for cell replacement therapy

Aiming to develop a practical way to bring stem cell transplants to clinical trials and beyond.

January 15 - December 17
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Functional and therapeutic approaches to congenital stationary night blindness

Researchers aim to improve the molecular diagnoses for a number of eye conditions by verifying computational modelling predictions of variants of unknown significance in the calcium ion channel Cav1.4.

October 18 - September 21
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