Our research

Fight for Sight funds pioneering research to prevent sight loss and treat eye disease in adults and children. Each year, we provide a range of funding opportunities for research teams based in the UK who are attached to recognised academic or medical institutions. You can read summaries of our research projects below.

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Cell-cell junctions in retinal disease: The role of ARHGEF18/p114RhoGEF

Researchers aim to identify the molecular mechanisms by which defective p114RhoGEF leads to malfunctioning of cell-cell junctions in retinal pigment epithelial cells and photoreceptors, and how such defects lead to degeneration of these cell types.

October 18 - September 21
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Investigating the unexpected role of transport motors inside light-detector cells

A new line of research that could lead to developing treatment for inherited retinal disorders

October 16 - September 19
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Investigation and treatment of intronic ABCA4 mutations in patients with inherited retinal dystrophy

A proportion of the causative mutations include those that occur within introns of the gene.

October 17 - September 20
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Novel genomic approaches in the elucidation of inherited retinal disease

October 17 - October 20
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Molecular mechanism of opsin transport and its relevance to photoreceptor degeneration

The aim is to identify proteins that bind opsin and move it into the photoreceptor outer segment.

September 18 - August 21
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Searching for more of the genes behind inherited central vision loss

Taking the first step towards targeted treatment and helping families plan for the future

January 15 - February 16
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Overcoming the barriers to gene therapy in Leber congenital amaurosis

Finding out which patients might benefit in a step towards clinical trials.

April 15 - August 15
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Understanding inherited blindness due to light-sensor cells with ‘broken antennas’

Identifying targets for treatment and potential new drugs to prevent damage to the retina in Bardet Biedl syndrome

February 15 - January 16
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Choosing the right cells for cell replacement therapy

Aiming to develop a practical way to bring stem cell transplants to clinical trials and beyond.

January 15 - December 17
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Functional and therapeutic approaches to congenital stationary night blindness

Researchers aim to improve the molecular diagnoses for a number of eye conditions by verifying computational modelling predictions of variants of unknown significance in the calcium ion channel Cav1.4.

October 18 - September 21
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