Project details
Type of funding:
Project grant
Grant holder:
Seabra, Miguel (Prof)
Institute:
Imperial College London
Conditions:
Choroideremia
Start date:
Sep 2006
Title:
Investigating the feasibility of gene therapy for treating choroideremia
Description:
Choroideremia is a recessive hereditary X-linked eye disease characterised by degeneration of the retinal pigment epithelium, photoreceptors and choroid.
Affected individuals, usually male, develop night blindness in their teens, which progresses to tunnel vision and blindness 20 to 30 years after the onset. There is no current treatment for the disease.
The disease is caused by loss of function of the CHM gene. The aim of this research is to investigate the feasibility for CHM gene therapy to restore sight and to pave the way for future gene therapy trials.
This project is ongoing.