What is it?
Trachoma is an infectious eye condition. The infection usually begins in early childhood and often leads to the eyelashes turning inwards (trichiasis).
Sight loss from trachoma happens over time. When the eyelashes turn in, they scratch the cornea (the clear front surface of the eye). Eventually, the cornea becomes too scratched for light to pass through. It’s a major cause of blindness in many developing countries.
Trachoma is triggered by repeat infection with bacteria known as Chlamydia trachomatis. The infection makes the lining of the eyelid (the conjunctiva) become inflamed.
The infection itself can be treated with antibiotics, but the inflammation can last long after the bacteria are gone. Long-term (chronic) inflammation makes the conjunctiva scarred and tight. This is what pulls the eyelashes inwards.
The first symptoms of infection include discharge from the eyes, redness and irritated eyes. Later on, the eyes get inflamed and scar. It’s painful when the eyelashes rub the cornea.
The infection causing trachoma can be cured with antibiotics, but the condition often continues and gets worse because of repeated infection and long-term inflammation.
Eyelid surgery can be done to correct the lashes that have turned inwards. The aim is to prevent pain and sight loss, but it doesn’t always work as the inflammation may still continue.
In order to prevent blindness from trachoma it is very important to understand how and why eye inflammation can continue even after the initial infection is gone. If we can find out, it may be possible to develop a treatment to control the inflammation so that the eyelashes never turn inward and scar the cornea.Read our research projects
You could play an important part in eye research by being a participant in clinical research study that may benefit many people. You could even help shape clinical research by becoming more actively involved and having a say. Patients, carer, or anyone with an interest can help.
What are clinical trials
Clinical trials are research studies that find out if a medical strategy, treatment, or device is safe and effective for humans. They are a key research tool for improving medical knowledge and patient care. The people who carry out research are mostly the same doctors and healthcare professionals who treat people. Their aim is to find better ways of treating patients and keeping people healthy.
Here are some ways to find out about research projects and clinical trials that you can get involved in.
UK Clinical Trials Gateway
The UK Clinical Trials Gateway run by the National Institute for Health Research (NIHR) provides easy to understand information about clinical research trials running in the UK, and gives to a large range of information about these trials. It is designed to enable patients and clinicians to locate and contact trials of interest. Visit their website and select the eye condition that you are interested in.
NIHR Clinical Research Network Portfolio
The NIHR Clinical Research Network Portfolio is a database of high-quality clinical research studies in England, Northern Ireland, Scotland and Wales. Within this the Ophthalmology Specialty Group supports a national portfolio of research studies in ophthalmology and the vision sciences. See their website for details.
If you wish to join a trial it is always best to discuss this with your doctor or clinical team first.
Last updated August 2015
Dr Matthew Burton, London School of Hygiene and Tropical Medicine