Seeing beyond visual acuity: Validating child-friendly visual function tests for Stargardt Disease

Brief plain language background 

STGD1 is a genetic eye condition that causes loss of central vision, typically starting in childhood or adolescence. It is the most common form of inherited macular dystrophy and currently has no approved treatments. As researchers work on developing new therapies, we need better tools to measure whether those treatments are working. This study will test new, tablet-based vision assessments that are engaging, easy to use, and designed to reflect everyday visual challenges more accurately.  

What problem/knowledge gap does it help address 

Current clinical trials for STGD1 mainly use standard vision tests like reading eye charts or looking at images of the back of the eye. These tests often miss subtle changes in vision and do not always reflect the real challenges patients face, such as recognising faces or finding things in cluttered environments or seeing in different light conditions. These limitations make it hard to measure the true impact of treatments. There is a need for new, sensitive, and meaningful tests that work for both adults and young people with Stargardt disease, especially tests that can detect changes over shorter periods.  

Aim of the project 

To evaluate and validate child-friendly, iPad-based visual function tests in a group of patients with Stargardt disease. 

Potential impact on people with sight loss 

This research has the potential to directly influence the design of upcoming clinical trials for Stargardt disease by providing functional outcome measures that are meaningful to patients’ daily lives. Establishing these tests as viable metrics can improve the evaluation of treatment efficacy, ultimately accelerating access to therapies and enhancing quality of life for those affected.