Research

Understanding a molecular mechanism as a cause of retinitis pigmentosa

Exploring the molecular mechanism of a new cause of autosomal dominant retinitis pigmentosa and potential therapies.

Optogenetic therapy with CRISPR-assisted activation of rhodopsin

Investigating alternative genetic causes of Retinitis Pigmentosa

The aim of the project is to understand if alterations in a gene called ARL13B, are present in patients with retinitis pigmentosa (RP), and to characterise how those alterations affect retinal cells.

Making a vital component of gene therapy for retinitis pigmentosa that can be used in clinical trials

Improving on a treatment that works well in animals with a natural form of severe sight loss

Developing a safe 'designer drug' to correct the genetic faults behind inherited eye disorders

A clever approach to treatment that could potentially restore sight

Can we repair ‘misfolding’ proteins in a common type of retinitis pigmentosa?

Looking for substances that can make the light-detecting pigment rhodopsin more stable.

How does scarring in the retina affect the chances of successful cell replacement therapy?

A look at the differences between inherited eye disorders

Ensuring safety of channelrhodopsin optogenetic therapies for vision restoration

Improving healthcare services for people with inherited retinal dystrophies: an evidence-based approach.

A research programme to reduce inequality, provide information and increase the options open to patients and families