Research

TIGER: Surgical Trial

Vitrectomy, subretinal Tissue plasminogen activator and Intravitreal Gas for submacular haemorrhage secondary to Exudative age-Related macular degeneration (TIGER): a European randomised controlled surgical trial.

Developing hybrid antimicrobial peptides to treat corneal infection

The aim of the project is to design and develop a novel class of antimicrobial agent - human-derived hybrid AMPs - to treat corneal infection.

Sub-retinal blood vessel damage and the development of dry AMD

The role of EPCR in choriocapillaris atrophy during age-related macular degeneration (AMD).

Pre-clinical research to treat bacteria leading to sight loss and hospitalisation

Optimising radiosensitivity of uveal melanoma by targeting DNA damage response

Researchers investigate how cancer responds to x-ray therapy proton beam therapy. This will identify drug strategies that can optimise radiotherapy treatment in promoting UM cell killing.

Investigating genetics underlying inherited corneal disease

Researchers seek to identify the underlying genetic mutations that cause inherited corneal disease.

CRISPR activation for inherited blindness

UCL researchers are using gene-editing technique CRISPRa to replace the damaged OPA1 gene which leads to blindness.

Genotype-phenotype study of CRB1-retinopathy

To improve understanding of the natural history (or progression) of inherited retinopathies caused by faults in the CRB1 gene.

Uncovering the link between arthritis and sight loss in children

Research will the hypothesis that uveitis development in Juvenile Idiopathic Arthritis (JIA) is driven by changes to B-cell function.